Detalhe da pesquisa
1.
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication.
Genes Dev
; 35(13-14): 1005-1019, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34168039
2.
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and ß2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Bioorg Med Chem Lett
; 41: 127975, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753262
3.
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ß2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
J Med Chem
; 65(15): 10233-10250, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35901125
4.
Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease.
J Med Chem
; 64(13): 9100-9119, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142835
5.
Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(8): 2235-9, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19318248
6.
The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.
Neuropharmacology
; 50(6): 677-89, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16430927
7.
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
J Med Chem
; 49(1): 35-8, 2006 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16392789
8.
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
J Med Chem
; 49(8): 2600-10, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610803
9.
Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System.
ACS Med Chem Lett
; 6(8): 925-9, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288695
10.
Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
ACS Med Chem Lett
; 1(7): 350-4, 2010 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900218
11.
Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands.
Bioorg Med Chem Lett
; 16(5): 1175-9, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16406613
12.
Pyrazolopyridinones as functionally selective GABAA ligands.
Bioorg Med Chem Lett
; 15(22): 4998-5002, 2005 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16153832